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NFL

NBA

MLB

NCAAF

NCAAB

Louisville
Cardinals

RECORD (CONF)

0 - 0 (0 - 0)

CONFERENCE

10th in ACC

AP RANK (TREND)

24 (24)

Place a Bet

To win next game

9/06 @

MISSMISS

To win conference

To win 2027 CFP Championship

What Place a Bet means

Louisville Cardinals odds to win conference are +240
Louisville Cardinals odds to win 2027 CFP Championship are +15000

Louisville Cardinals Betting Odds Today

Next Game

Louisville Cardinals

0-0 (0-0) | 10th in Atlantic Coast

SPREAD

MONEYLINE

TOTAL

@

Ole Miss Rebels

0-0 (0-0) | 11th in Southeastern

SPREAD

MONEYLINE

TOTAL

SUN SEPTEMBER 6, 2026 | 11:30PM UTC

NISSAN STADIUM | OUTDOOR

Louisville Cardinals Regular Season Schedule

Week

Date

Opponent

Result (Conf)

Time

Network

Venue

1

Sun, Sep 6

@

Ole Miss RebelsMISS

-

11:30pm UTC

ABC

Nissan Stadium

2

Fri, Sep 11

vs

Villanova Wildcats

-

11:00pm UTC

ACC Network

L&N Federal Credit Union Stadium

3

Sat, Sep 19

vs

SMU MustangsSMU

| ACC

-

7:30pm UTC

ESPN Networks

L&N Federal Credit Union Stadium

4

Sat, Sep 26

vs

Wake Forest Demon DeaconsWAKE

| ACC

-

5:00pm UTC

-

L&N Federal Credit Union Stadium

5

Sat, Oct 3

@

NC State WolfpackNCST

| ACC

-

5:00pm UTC

-

Wayne Day Family Field at Carter-Finley Stadium

6

Fri, Oct 9

vs

Florida State SeminolesFSU

| ACC

-

11:00pm UTC

ESPN

L&N Federal Credit Union Stadium

7

Sat, Oct 17

@

Syracuse OrangeSYR

| ACC

-

5:00pm UTC

-

JMA Wireless Dome

8

BYE WEEK

9

Sat, Oct 31

vs

Stanford CardinalSTAN

| ACC

-

5:00pm UTC

-

L&N Federal Credit Union Stadium

10

Sat, Nov 7

@

Georgia Tech Yellow JacketsGT

| ACC

-

6:00pm UTC

-

Bobby Dodd Stadium at Hyundai Field

11

Sat, Nov 14

@

North Carolina Tar HeelsUNC

| ACC

-

6:00pm UTC

-

Kenan Stadium

12

Sat, Nov 21

vs

Pittsburgh PanthersPITT

| ACC

-

6:00pm UTC

-

L&N Federal Credit Union Stadium

13

Sat, Nov 28

@

Kentucky WildcatsUK

-

6:00pm UTC

-

Kroger Field

Louisville Cardinals National Championship Odds
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Louisville Cardinals Betting in 2026

The Louisville Cardinals capped the 2025 season with a strong 9–4 finish, including a dominant 41–0 rivalry shutout of Kentucky and a 27–22 victory over Toledo in the Boca Raton Bowl, while going 4–4 in ACC play. Offensively, Jeff Brohm's balanced attack leaned on explosive backs Isaac Brown and Keyjuan Brown, helping Louisville average nearly 30 points and almost 385 yards per game. At receiver, first-team All-ACC wideout Chris Bell and all-purpose standout Caullin Lacy were key contributors in 2025, though both have since departed for the NFL ahead of the 2026 season. Defensively, leaders like linebacker TJ Quinn, edge rusher Clev Lubin, cornerback Tayon Holloway, safety D'Angelo Hutchinson, and versatile linebacker Antonio Watts anchored a unit that kept opponents to just over 21 points per contest. With Brohm's staff largely intact and the ACC's expanded slate including programs like SMU and Stanford, the Cardinals face a deeper but navigable conference schedule. Louisville will need to develop new contributors at receiver and linebacker following the departures of Bell, Lacy, Quinn, and Hutchinson to the NFL, though the return of Isaac Brown and Keyjuan Brown provides a strong foundation in the backfield. For fans tracking futures markets, current NCAAF betting odds can provide an additional snapshot of expectations heading into 2026.

Within the national picture, Louisville sits a tier below preseason blue blood favorites but remains a credible riser in an evolving ACC landscape. FanDuel Sportsbook currently lists the Cardinals at +12500 to win the 2027 College Football Playoff National Championship, reflecting solid respect but acknowledging the gap to perennial contenders like Ohio State, Notre Dame, and Texas. To close that gap, Louisville will need to reload at skill positions following key NFL departures, sustain an efficient ground game behind returning backs Isaac Brown and Keyjuan Brown, and develop its passing attack against a schedule that includes Ole Miss, SMU, and Florida State. Long term, Brohm's program is focused on stacking winning seasons, leveraging recent success into recruiting momentum, and building depth capable of navigating a 12-team CFP era. If those pieces come together, Louisville can gradually move from conference dark horse to legitimate factor in the broader National Championship odds boards.