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NFL

NBA

MLB

NCAAF

NCAAB

Louisville
Cardinals

RECORD (CONF)

8 - 4 (4 - 4)

CONFERENCE

10th in ACC

AP RANK (TREND)

NR

Place a Bet

To win next game

9/06 @

MISSMISS

To win conference

To win 2027 CFP Championship

What Place a Bet means

Louisville Cardinals odds to win conference are +800
Louisville Cardinals odds to win 2027 CFP Championship are +12500

Louisville Cardinals Betting Odds Today

Next Game

Louisville Cardinals

8-4 (4-4) | 10th in Atlantic Coast

SPREAD

MONEYLINE

TOTAL

@

Ole Miss Rebels

12-1 (7-1) | 3rd in Southeastern

SPREAD

MONEYLINE

TOTAL

SUN SEPTEMBER 6, 2026 | 11:30PM UTC

NISSAN STADIUM | OUTDOOR

Louisville Cardinals Regular Season Schedule

Week

Date

Opponent

Result (Conf)

Time

Network

Venue

1

Sun, Sep 6

@

Ole Miss RebelsMISS

-

11:30pm UTC

ABC

Nissan Stadium

2

Fri, Sep 11

vs

Villanova Wildcats

-

11:00pm UTC

ACC Network

L&N Federal Credit Union Stadium

3

Sat, Sep 19

vs

SMU MustangsSMU

| ACC

-

7:30pm UTC

ESPN Networks

L&N Federal Credit Union Stadium

4

Sat, Sep 26

vs

Wake Forest Demon DeaconsWAKE

| ACC

-

5:00pm UTC

-

L&N Federal Credit Union Stadium

5

Sat, Oct 3

@

NC State WolfpackNCST

| ACC

-

5:00pm UTC

-

Wayne Day Family Field at Carter-Finley Stadium

6

Fri, Oct 9

vs

Florida State SeminolesFSU

| ACC

-

11:00pm UTC

ESPN

L&N Federal Credit Union Stadium

7

Sat, Oct 17

@

Syracuse OrangeSYR

| ACC

-

5:00pm UTC

-

JMA Wireless Dome

8

BYE WEEK

9

Sat, Oct 31

vs

Stanford CardinalSTAN

| ACC

-

5:00pm UTC

-

L&N Federal Credit Union Stadium

10

Sat, Nov 7

@

Georgia Tech Yellow JacketsGT

| ACC

-

6:00pm UTC

-

Bobby Dodd Stadium at Hyundai Field

11

Sat, Nov 14

@

North Carolina Tar HeelsUNC

| ACC

-

6:00pm UTC

-

Kenan Stadium

12

Sat, Nov 21

vs

Pittsburgh PanthersPITT

| ACC

-

6:00pm UTC

-

L&N Federal Credit Union Stadium

13

Sat, Nov 28

@

Kentucky WildcatsUK

-

6:00pm UTC

-

Kroger Field

Louisville Cardinals National Championship Odds
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Louisville Cardinals Betting in 2026

The Louisville Cardinals wrapped up a strong 2024 campaign at 9-4 overall and 5-3 in the ACC, highlighted by a statement win over Clemson. Under the steady leadership of head coach Jeff Brohm, the team showcased balance, ranking 33rd nationally in rushing yards per game (185.2) while leaning on quarterback Miller Moss, wide receiver Chris Bell, and a potent backfield duo of Duke Watson and Isaac Brown. The Cardinals enter 2025 with 17 upperclassmen starters returning, a rare luxury in today’s transfer-driven landscape. Louisville was aggressive in the portal, adding 30 transfers, most notably defensive lineman Jerry Lawson, who posted 14 tackles for loss last season, to bolster depth and physicality. The primary challenge lies in integrating several new faces along the offensive line, which will be key to maintaining the ground game’s efficiency. With continuity at skill positions and a deep veteran presence, Louisville’s goals include pushing for double-digit wins again, securing ACC title contention, and earning a postseason berth in the expanded playoff field. The Cardinals’ NCAAF betting odds suggest a program trending toward sustained relevance.

Louisville enters 2025 considered a dark horse and has received votes in some preseason polls, positioning them within the ACC race. While the conference boasts perennial powers, the Cardinals’ combination of veteran leadership, portal upgrades, and offensive continuity gives them a realistic shot at pushing into the top 15 if early-season chemistry develops quickly. Their chances of reaching the College Football Playoff will hinge on trench play, both protecting Miller Moss and generating consistent defensive pressure. With a manageable schedule and a solid core of returning starters, Louisville has the framework to outperform expectations and contend for a New Year’s Six bowl. Recruiting momentum and transfer wins also point to a healthy long-term trajectory, with the program clearly intent on building a sustainable contender. Check the latest National Championship odds and CFB playoff odds to gauge Louisville’s standing in what could be a breakthrough season for the Cardinals.