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NFL

NBA

MLB

NCAAF

NCAAB

Louisville
Cardinals

RECORD (CONF)

5 - 1 (2 - 1)

CONFERENCE

8th in ACC

AP RANK (TREND)

NR

Place a Bet

To win next game

10/25 vs

BCBC

To win conference

To win 2026 CFP Championship

What Place a Bet means

Louisville Cardinals odds to win 2026 CFP Championship are +12500

Louisville Cardinals Betting Odds Today

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Boston College Eagles

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Louisville Cardinals

5-1 (2-1) | 8th in Atlantic Coast

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SAT OCTOBER 25, 2025 | 11:30PM UTC

L&N FEDERAL CREDIT UNION STADIUM | OUTDOOR

Louisville Cardinals Regular Season Schedule for 2025

Week

Date

Opponent

Result (Conf)

Time

Network

Venue

1

Sat, Aug 30

vs

Eastern Kentucky Colonels

W

51 - 17

7:00pm UTC

ACC Network

L&N Federal Credit Union Stadium

2

Fri, Sep 5

vs

James Madison DukesJMU

W

28 - 14

11:00pm UTC

ESPN2

L&N Federal Credit Union Stadium

3

BYE WEEK

4

Sat, Sep 20

vs

Bowling Green FalconsBGSU

W

40 - 17

4:00pm UTC

ACC Network

L&N Federal Credit Union Stadium

5

Sat, Sep 27

@

Pittsburgh PanthersPITT

| ACC

W

34 - 27 (1 - 0)

4:00pm UTC

ESPN2

Acrisure Stadium

6

Sat, Oct 4

vs

Virginia CavaliersUVA

| ACC

L

27 - 30 (1 - 1)

7:30pm UTC

ESPN2

L&N Federal Credit Union Stadium

7

BYE WEEK

8

Fri, Oct 17

@

Miami (FL) HurricanesMIA

| ACC

W

24 - 21 (2 - 1)

11:00pm UTC

ESPN

Hard Rock Stadium

9

Sat, Oct 25

vs

Boston College EaglesBC

| ACC

-

11:30pm UTC

ACC Network

L&N Federal Credit Union Stadium

10

Sat, Nov 1

@

Virginia Tech HokiesVT

| ACC

-

5:00pm UTC

-

Lane Stadium

11

Sat, Nov 8

vs

California Golden BearsCAL

| ACC

-

6:00pm UTC

-

L&N Federal Credit Union Stadium

12

Sat, Nov 15

vs

Clemson TigersCLEM

| ACC

-

12:30am UTC

ESPN

L&N Federal Credit Union Stadium

13

Sat, Nov 22

@

SMU MustangsSMU

| ACC

-

6:00pm UTC

-

Gerald J. Ford Stadium

14

Sat, Nov 29

vs

Kentucky WildcatsUK

-

6:00pm UTC

-

L&N Federal Credit Union Stadium

Louisville Cardinals National Championship Odds
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Louisville Cardinals Betting in 2025

The Louisville Cardinals wrapped up a strong 2024 campaign at 9-4 overall and 5-3 in the ACC, highlighted by a statement win over Clemson. Under the steady leadership of head coach Jeff Brohm, the team showcased balance, ranking 33rd nationally in rushing yards per game (185.2) while leaning on quarterback Miller Moss, wide receiver Chris Bell, and a potent backfield duo of Duke Watson and Isaac Brown. The Cardinals enter 2025 with 17 upperclassmen starters returning, a rare luxury in today’s transfer-driven landscape. Louisville was aggressive in the portal, adding 30 transfers, most notably defensive lineman Jerry Lawson, who posted 14 tackles for loss last season, to bolster depth and physicality. The primary challenge lies in integrating several new faces along the offensive line, which will be key to maintaining the ground game’s efficiency. With continuity at skill positions and a deep veteran presence, Louisville’s goals include pushing for double-digit wins again, securing ACC title contention, and earning a postseason berth in the expanded playoff field. The Cardinals’ NCAAF betting odds suggest a program trending toward sustained relevance.

Louisville enters 2025 considered a dark horse and has received votes in some preseason polls, positioning them within the ACC race. While the conference boasts perennial powers, the Cardinals’ combination of veteran leadership, portal upgrades, and offensive continuity gives them a realistic shot at pushing into the top 15 if early-season chemistry develops quickly. Their chances of reaching the College Football Playoff will hinge on trench play, both protecting Miller Moss and generating consistent defensive pressure. With a manageable schedule and a solid core of returning starters, Louisville has the framework to outperform expectations and contend for a New Year’s Six bowl. Recruiting momentum and transfer wins also point to a healthy long-term trajectory, with the program clearly intent on building a sustainable contender. Check the latest National Championship odds and CFB playoff odds to gauge Louisville’s standing in what could be a breakthrough season for the Cardinals.